Download and read online Handbook of Safety Assessment of Nanomaterials in PDF and EPUB The rapidly evolving field of nanomedicine refers to the clinical application of nanotechnologies. However, as with all new technologies, there are ethical, safety, and regulatory issues. This handbook, written by leading international experts, provides a meticulous overview of the state of the art of safety assessment of nanomaterials (nanotoxicology) in the context of their application in nanomedicine. The volume includes a historical perspective on the development of nanomedicine and its regulation, and a personal view of the future of (nano)medicine by Patrick Hunziker, president of the European Society of Nanomedicine. Ethical considerations in relation to nanomedicine are discussed. There are a series of chapters on organ-specific toxicities of nanomaterials, including pulmonary and cardiovascular toxicity, neurotoxicity, dermatotoxicity, and reproductive toxicity, as well as a discussion on immunotoxicity and genotoxicity. The importance of a thorough characterization of physicochemical properties of nanomaterials is emphasized. The handbook also contains a critical discussion on the applicability of in vitro versus in vivo methods and models for nanosafety assessment, along with an introduction to mathematical modeling approaches with a view to a predictive toxicology of nanomaterials. The overall aim is to provide a comprehensive, science-based framework for safety assessment of current and future nanomedicines.
Download and read online Handbook of Nanosafety in PDF and EPUB Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace. Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM. Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment. Multi-authored book, written by leading researchers in the field of nanotoxicology and nanosafety Features state-of-the-art physical and chemical characterization of engineered nanomaterials (ENM) Develops strategies for exposure assessment, risk assessment and risk management Includes practical case studies and exposure scenarios to demonstrate how you can safely use ENM in the workplace
Download and read online The Handbook of Nanomedicine in PDF and EPUB This handbook covers the broad scope of nanomedicine. Starting with the basics, the subject is developed to potential clinical applications, many of which are still at an experimental stage. The book features extensive coverage of nanodiagnostics and nanopharmaceuticals, which are two important components of nanomedicine. Written by a physician-scientist author who blends his clinical experience and scientific expertise in new technologies, this book provides a definitive account of nanomedicine. It offers more up-to-date and comprehensive coverage of nanomedicine than any other comparable work.
Download and read online Handbook of Nanobiomedical Research in PDF and EPUB This book consists of 4 volumes containing about 70 chapters covering all the major aspects of the growing area of nanomedicine. Leading scientists from 15 countries cover all major areas of nanobiomedical research — materials for nanomedicine, application of nanomedicine in therapy of various diseases, use of nanomedicines for diagnostic purposes, technology of nanomedicines, and new trends in nanobiomedical research. This is the first detailed handbook specifically addressing various aspects of nanobiomedicine. Readers are treated to cutting-edge research and the newest data from leading researchers in this area. Contents:Materials for Nanomedicine:Liposomal Nanomedicines (Amr S Abu Lila, Tatsuhiro Ishida and Theresa M Allen)Solid Lipid Nanoparticles for Biomedical Applications (Karsten Mäder)Micellar Nanopreparations for Medicine (Rupa Sawant and Aditi Jhaveri)Nanoemulsions in Medicine (William B Tucker and Sandro Mecozzi)Drug Nanocrystals and Nanosuspensions in Medicine (Leena Peltonen, Jouni Hirvonen and Timo Laaksonen)Polymeric Nanosystems for Integrated Image-Guided Cancer Therapy (Amit Singh, Arun K Iyer and Mansoor M Amiji)Polysaccharide-Based Nanocarriers for Drug Delivery (Carmen Teijeiro, Adam McGlone, Noemi Csaba, Marcos Garcia-Fuentes and María J Alonso)Dendrimers for Biomedical Applications (Lisa M Kaminskas, Victoria M McLeod, Seth A Jones, Ben J Boyd and Christopher J H Porter)Layer-by-Layer Nanopreparations for Medicine — Smart Polyelectrolyte Multilayer Capsules and Coatings (Rawil F Fakhrullin, Gleb B Sukhorukov and Yuri M Lvov)Inorganic Nanopreparations for Nanomedicine (James Ramos and Kaushal Rege)Silica-Based Nanoparticles for Biomedical Imaging and Drug Delivery Applications (Stephanie A Kramer and Wenbin Lin)Carbon Nanotubes in Biomedical Applications (Krunal K Mehta, Elena E Paskaleva, Jonathan S Dordick and Ravi S Kane)Core-Shell Nanoparticles for Biomedical Applications (Mahmoud Elsabahy and Karen L Wooley)Structure–Activity Relationships for Tumor-Targeting Gold Nanoparticles (Erik C Dreaden, Ivan H El-Sayed and Mostafa A El-Sayed)Silver Nanoparticles as Novel Antibacterial and Antiviral Agents (Stefania Galdiero, Annarita Falanga, Marco Cantisani, Avinash Ingle, Massimiliano Galdiero and Mahendra Rai)Magnetic Nanoparticles for Drug Delivery (Rainer Tietze, Harald Unterweger and Christoph Alexiou)Quantum Dots as a Platform Nanomaterial for Biomedical Applications (Eleonora Petryayeva, Roza Bidshahri, Kate Liu, Charles A Haynes, Igor L Medintz, and W Russ Algar)Applications in Therapy:The Application of Nanomedicine to Cardiovascular Diseases (Kevin M Bardon, Olivier Kister and Jason R McCarthy)Nanomedicines for Restenosis Therapy (J E Tengood, I Fishbein, R J Levy and M Chorny)Nanopreparations for Cancer Treatment and Diagnostics (Jayant Khandare, Shashwat Banerjee and Tamara Minko)Nanoparticles in the Gastrointestinal Tract (Abraham Rubinstein)Nanopreparations for Oral Administration (D Hubbard, D J Brayden and H Ghandehari)Nanopreparations for Central Nervous System Diseases (Leyuan Xu and Hu Yang)Nanoparticles for Dermal and Transdermal Delivery: Permeation Pathways and Applications (Marianna Foldvari, Marjan Gharagozloo and Christine Li)Lysosomes and Nanotherapeutics: Diseases, Treatments, and Side Effects (Rachel L Manthe and Silvia Muro)Nanostructured Biomaterials for Inhibiting Cancer Cell Functions (Lijuan Zhang and Thomas J Webster)Nanomedicine in Otorhinolaryngology (Carl Philpott)Nanomedicines for Ocular Administration (Yolanda Diebold)Nano-antibiotics: Nanotechnology in Fighting Against Infectious Diseases (Jessica Kemp, Julius Edson, Young Jik Kwon)Nanoparticles as Adjuvants for Vaccination (Juan M Irache, Ana I Camacho and Carlos Gamazo)Nanopreparations for Gene Delivery (Viola B Morris and Vinod Labhasetwar)Cancer Hyperthermia Using Nanomagnetic Particles and Induction of Immune Responses (Takeshi Kobayashi)Clinical Experience with Liposomal Doxorubicin (Giuseppe Visani and Alessandro Isidori)Clinical Experience with Nanoparticle Albumin Bound (Nab) Paclitaxel (Abraxane®) (Prakash Vishnu and Vivek Roy)Applications in Diagnostics:Nano Advantages in Diagnostic Imaging (William T Phillips and Beth Goins)Superparamagnetic Iron Oxides as Imaging Probes of Metastases and Vulnerable Atherosclerotic Plaques (Mary L Mazzanti and Alexei A Bogdanov, Jr)Nanoparticulate Contrast Agents for CT, SPECT and PET Imaging (Suna Erdogan and Mine Silindir)Nanotargeted Radiopharmaceuticals for Nuclear Imaging and Radiotherapy (Gann Ting, Yun-Long Tseng, Chih-Hsien Chang and Te-Wei Lee)Nanoengineering at the Gas–Liquid Interface: Gas-Filled Microbubbles as Tools for Molecular Imaging and Drug Delivery (Alexander L Klibanov)Nanotechnology for Multimodality Imaging: Applications in Disease Detection and Treatment Guidance (Jinzi Zheng, Raquel De Souza David Jaffray and Christine Allen)Theranostic Nanopreparations for Medicine (Anthony J McGoron)Fluorescent Silica Nanoparticles for Medical Imaging (Jeremy Tharkur, Maria Alejandra Ricaurte and Swadeshmukul Santra)Engineered Gold Nanoparticles as Contrast Agents for Biological Medical Imaging (Anna M Sitarski, Sanjeev Kandpal, Jeremy Grant, Andrew Doolittle, Matthew Newsom and Michael D Mason)Photoluminescent Nanoparticles for Optical Imaging in Biology and Medicine (María Teresa Fernández-Argüelles, Rosario Pereiro, José M Costa-Fernández and Alfredo Sanz-Medel)Metal Particles for Photoacoustic Imaging (Dipanjan Pan)Nanoelectrodes for Biomedical Applications (Haibin Shi and Joanne I Yeh)Nanosensors for Biomedicine (Mary K Balaconis and Heather A Clark)In Vivo Photoacoustic Detection of Circulating Cells and Nanoparticles (Jin-Woo Kim, Ekaterina I Galanzha and Vladimir P Zharov)Raman Micro-Spectroscopy as a Non-Invasive Tool to Follow the Intracellular Fate of Nanoparticles (Tatyana Chernenko, Max Diem and Vladimir Torchilin)Clinical Experience with Nanoparticles in Imaging (Patrick D Sutphin and Mukesh Harisinghani)Biology, Safety and Novel Concepts in Nanomedicine:Biology and Safety:Biological Requirement and Safety Assessment of Nanomedicines (Banu Zolnik, Simona Bancos, Jae Seung Kim and Nakissa Sadrieh)Anatomical and Physicochemical Factors Controlling Nanoparticle Pharmacokinetics (S M Moghimi and Z S Farhangrazi)Immunological Issues with Nanomedicines: Immunogenicity, Hypersensitivity, Accelerated Clearance and Immune Suppression (Janos Szebeni and Wim Jiskoot)Toxicology of Mesoporous Silica Particles and Their Uses in Nanomedicine (Xin Xia, Natalia Kupferschmidt and Alfonso E Garcia-Bennett)Cellular Responses Induced by Nanoparticles (Masanori Horie)Regulatory Aspects of Pharmaceutical Nanopreparations (Gerard M Jensen and Linda Soo Hoo)A Short Course on the Chemistry Manufacturing and Control of Liposome-based Pharmaceutical Products (Simon Eastman and Tom Redelmeier)Preclinical to Clinical Development of Nanomedicines (Sonke Svenson)Novel Concepts in Nanomedicine:Organelle-Targeted Nanocarriers (Alexander Koshkaryev)Bacteriophage-Targeted Nanomedicine and Molecular Imaging (Tao Wang and Radhika Narayanaswamy)Stimuli-Sensitive Nanostructured Systems for Biomedical Applications (Barbara Blanco-Fernandez, Angel Concheiro and Carmen Alvarez-Lorenzo)Biomedical Nanopreparations with Controlled Geometry (Catherine A Fromen, Stuart S Dunn and Joseph M DeSimone)Biomimetic Systems in Nanomedicine (Ana Maria Carmona-Ribeiro)Nanoreactors for Biomedical Applications (Fabian Itel, Ionel Adrian Dinu, Pascal Tanner, Ozana Fischer and Cornelia G Palivan)"Click" Reactions: An Emerging Tool for Biology (Annie Castonguay and Dusica Maysinger) Readership: Academics, researchers, graduate students and professionals interested in contemporary nanomedicine. Keywords:Nanomedicine;Drug Delivery Systems;Materials for Nanomedicine;Nanomedicine in Therapy;Nanomedicine in Diagnostics;NanoparticlesKey Features:Covers the whole field of nanobiomedicineIncludes chapters from many leading world renowned scientistsProvides cutting-edge data
Download and read online CRC Handbook of Chemistry and Physics 97th Edition in PDF and EPUB Proudly serving the scientific community for over a century, this 97th edition of the CRC Handbook of Chemistry and Physics is an update of a classic reference, mirroring the growth and direction of science. This venerable work continues to be the most accessed and respected scientific reference in the world. An authoritative resource consisting of tables of data and current international recommendations on nomenclature, symbols, and units, its usefulness spans not only the physical sciences but also related areas of biology, geology, and environmental science. The 97th edition of the Handbook includes 20 new or updated tables along with other updates and expansions. It is now also available as an eBook. This reference puts physical property data and mathematical formulas used in labs and classrooms every day within easy reach. New Tables: Surface Active Chemicals – Table of Properties of the Most Important Surfactants (Solubility, Physical Constants, Critical Micelle Concentration, Hydrophilic-Lipophilic Balance, etc.) Nanomaterial Safety Guidelines – Definition of Terms in Nanoscience; Guidelines for Safe Handling and Disposal Updated and Expanded Tables: CODATA Values of the Fundamental Physical Constants – 2014 values Standard Atomic Weights – 2015 Changes Made by IUPAC Atomic Masses and Abundances – Update of Abundances Surface Tension of Common Liquids – Addition of New Compounds and Updates Basic Instrumental Techniques of Analytical Chemistry – Expansion to Cover Colorimetry and Refractometry Bond Dissociation Energies – Addition of Recently Published Data Photon Attenuation Coefficients – Addition of Absorption Edge Data Classification of Electromagnetic Radiation – Update with Modern Terminology Astronomical Constants – Update with New Recommended Constants Solar System Properties – Updates with Newly Discovered Satellites Interstellar Molecules – Update with Complete List of Molecules Observed to Date Major World Earthquakes – Update through 2015 Atmospheric Concentration of CO2 – Update through 2015 Global Temperature Trend – Update through 2015 Abbreviations Used in the Assessment and Presentation of Laboratory Hazards – Update and Expansion Relative Dose Ranges for Ionizing Radiation – Expansion Threshold Limits for Airborne Contaminants – Update to 2015 Recommendations Chemical Carcinogens – Update to 2015 Recommendations of National Toxicology Program
Download and read online Aerosols Handbook in PDF and EPUB With the rapid growth of the nanotechnology industry, the need to understand the biological effects of aerosol exposure has become increasingly important. Featuring contributions by leading experts in the field, Aerosols Handbook: Measurement, Dosimetry, and Health Effects, Second Edition offers an up-to-date overview of many aspects of aerosols, from properties to health effects and epidemiology. Covering indoor, outdoor, industrial, medical, pharmaceutical, and radioactive aerosols, this book explores aerosol dosimetry by defining terms such as exposure and dose. In addition, it looks at nanometer particles, the mechanism of aerosol deposition in the lungs, and modeling deposition with a corresponding uncertainty in risk assessment. The text also emphasizes the importance of accurate aerosol measurements, particularly breathing zone exposure assessments. Examining radioactive aerosols, the book discusses lessons learned from nuclear accidents, radon and thoron, and long-lived radionuclides in the environment. It brings together research on both radioactive and nonradioactive aerosols, supplying readers with a more complete view of how aerosols behave in the lungs. New in This Edition Five new chapters that address the safety of nanomaterials, dealing with nanoparticle cell penetration, high aspect ratio nanomaterials, nanoaerosols in drug delivery, risk assessment, and health effects New chapters on atmospheric pollution related to climate change, chemical analyses of particle filter deposits, and classical nucleation theory New data on measurement, dosimetry, and health effects Updated throughout, this second edition continues to be an essential resource for those who study exposure, dosages, and toxicity to develop treatments for exposure, reduce air pollution, and establish better safety regulations, particularly in industries using nanotechnologies.
Download and read online Springer Handbook of Nanomaterials in PDF and EPUB The Springer Handbook of Nanomaterials covers the description of materials which have dimension on the "nanoscale". The description of the nanomaterials in this Handbook follows the thorough but concise explanation of the synergy of structure, properties, processing and applications of the given material. The Handbook mainly describes materials in their solid phase; exceptions might be e.g. small sized liquid aerosols or gas bubbles in liquids. The materials are organized by their dimensionality. Zero dimensional structures collect clusters, nanoparticles and quantum dots, one dimensional are nanowires and nanotubes, while two dimensional are represented by thin films and surfaces. The chapters in these larger topics are written on a specific materials and dimensionality combination, e.g. ceramic nanowires. Chapters are authored by well-established and well-known scientists of the particular field. They have measurable part of publications and an important role in establishing new knowledge of the particular field.
Download and read online Food Processing Handbook in PDF and EPUB The second edition of the Food Processing Handbook presents a comprehensive review of technologies, procedures and innovations in food processing, stressing topics vital to the food industry today and pinpointing the trends in future research and development. Focusing on the technology involved, this handbook describes the principles and the equipment used as well as the changes - physical, chemical, microbiological and organoleptic - that occur during food preservation. In so doing, the text covers in detail such techniques as post-harvest handling, thermal processing, evaporation and dehydration, freezing, irradiation, high-pressure processing, emerging technologies and packaging. Separation and conversion operations widely used in the food industry are also covered as are the processes of baking, extrusion and frying. In addition, it addresses current concerns about the safety of processed foods (including HACCP systems, traceability and hygienic design of plant) and control of food processes, as well as the impact of processing on the environment, water and waste treatment, lean manufacturing and the roles of nanotechnology and fermentation in food processing. This two-volume set is a must-have for scientists and engineers involved in food manufacture, research and development in both industry and academia, as well as students of food-related topics at undergraduate and postgraduate levels. From Reviews on the First Edition: "This work should become a standard text for students of food technology, and is worthy of a place on the bookshelf of anybody involved in the production of foods." Journal of Dairy Technology, August 2008 "This work will serve well as an excellent course resource or reference as it has well-written explanations for those new to the field and detailed equations for those needing greater depth." CHOICE, September 2006
Download and read online Handbook of Metal Microbe Interactions and Bioremediation in PDF and EPUB Around the World, metal pollution is a major problem. Conventional practices of toxic metal removal can be ineffective and/or expensive, delaying and exacerbating the crisis. Those communities dealing with contamination must be aware of the fundamentals advances of microbe-mediated metal removal practices because these methods can be easily used and require less remedial intervention. This book describes innovations and efficient applications for metal bioremediation for environments polluted by metal contaminates.
Download and read online Handbook of Environmental Degradation of Materials in PDF and EPUB Nothing stays the same for ever. The environmental degradation and corrosion of materials is inevitable and affects most aspects of life. In industrial settings, this inescapable fact has very significant financial, safety and environmental implications. The Handbook of Environmental Degradation of Materials explains how to measure, analyse, and control environmental degradation for a wide range of industrial materials including metals, polymers, ceramics, concrete, wood and textiles exposed to environmental factors such as weather, seawater, and fire. Divided into sections which deal with analysis, types of degradation, protection and surface engineering respectively, the reader is introduced to the wide variety of environmental effects and what can be done to control them. The expert contributors to this book provide a wealth of insider knowledge and engineering knowhow, complementing their explanations and advice with Case Studies from areas such as pipelines, tankers, packaging and chemical processing equipment ensures that the reader understands the practical measures that can be put in place to save money, lives and the environment The Handbook's broad scope introduces the reader to the effects of environmental degradation on a wide range of materials, including metals, plastics, concrete,wood and textiles. For each type of material, the book describes the kind of degradation that effects it and how best to protect it. Case Studies show how organizations from small consulting firms to corporate giants design and manufacture products that are more resistant to environmental effects.
Download and read online Engineered Nanoparticles and the Environment in PDF and EPUB Details the source, release, exposure, adsorption, aggregation, bioavailability, transport, transformation, and modeling of engineered nanoparticles found in many common products and applications Covers synthesis, environmental application, detection, and characterization of engineered nanoparticles Details the toxicity and risk assessment of engineered nanoparticles Includes topics on the transport, transformation, and modeling of engineered nanoparticles Presents the latest developments and knowledge of engineered nanoparticles Written by world leading experts from prestigious universities and companies
Download and read online Reproductive and Developmental Toxicology in PDF and EPUB Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. Provides a complete, integrated source of information on the key risk stages during reproduction and development Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
Download and read online Stem Cell Nanoengineering in PDF and EPUB Stem Cell Nanoengineering reviews the applications of nanotechnology in the fields of stem cells, tissue engineering, and regenerative medicine. Topics addressed include various types of stem cells, underlying principles of nanobiotechnology, the making of nano-scaffolds, nano tissue engineering, applications of nanotechnology in stem cell tracking and molecular imaging, nano-devices, as well as stem cell nano-engineering from bench to bedside. Written by renowned experts in their respective fields, chapters describe and explore a wide variety of topics in stem cell nanoengineering, making the book a valuable resource for both researchers and clinicians in biomedical and bioengineering fields.
Download and read online Occupational Safety and Hygiene IV in PDF and EPUB Occupational Safety and Hygiene IV covers a wide variety of topics, including but not limited to: - Occupational Safety - Risk Assessment - Ergonomics - Management Systems - Physical Environment - Construction Safety, and - Human Factors This compilation of papers in the domain of occupational safety and hygiene is mainly based on research works carried out at universities and other research institutions, and on practical studies developed by Occupational Safety & Health (OSH) practitioners within their companies. Accordingly, this book will be helpful to get acquainted with the state-of-the-art of the research within the mentioned domains, as well as with some practical tools and approaches that are currently used by OSH professionals in a global context.
Download and read online Hayes Handbook of Pesticide Toxicology in PDF and EPUB The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.